Zero Breast Cancer

ZERO BREAST CANCER'S (ZBC) MISSION IS TO PROMOTE BREAST CANCER RISK REDUCTION THROUGH TRANSLATION OF SCIENTIFIC RESEARCH AND EVIDENCE-BASED RECOMMENDATIONS THAT SUPPORT HEALTH AND WELLNESS AT KEY STAGES OF LIFE. WE ENVISION A WORLD WITH ZERO BREAST CANCER.

EDUCATIONAL AND OUTREACH PROGRAMS:ZBC PRODUCES CLEAR, RELEVANT, EVIDENCE-BASED EDUCATIONAL CONTENT TO RAISE AWARENESS OF SOCIAL AND BUILT ENVIRONMENT RISK FACTORS FOR BREAST CANCER AND PROVIDE PRACTICAL ADVICE FOR HOW TO REDUCE THAT RISK. TWO KEY STRATEGIES FOR REACHING OUR INTENDED AUDIENCE ARE 1) TO USE THE POWER OF THE INTERNET TO ENGAGE INTERESTED PARTIES AND 2) TO PARTNER WITH A VARIETY OF ORGANIZATIONS DIRECTLY SERVING THE COMMUNITIES AND DEMOGRAPHICS ZBC HAS DETERMINED TO BE OUR PRIORITIES. OUR MATERIALS WERE READILY AVAILABLE THROUGH FREQUENT, MULTICHANNEL DIGITAL COMMUNICATION INITIATIVES, INCLUDING BLOGS, NEWSLETTERS, AND FREQUENT SOCIAL MEDIA POSTS. OUR MATERIALS WERE ALSO SHARED AT VIRTUAL AND IN-PERSON HEALTH FAIRS AND PROMOTED IN OUR WEBINAR SERIES. IN 2022, ZBC CONTINUED TO COLLABORATE WITH COMMUNITY PARTNERS AS PART OF OUR DISSEMINATION PLAN FOR ZBC MATERIALS TO REACH LOWER-INCOME AND HIGHER-NEED COMMUNITIES IN THE GREATER SAN FRANCISCO BAY AREA AND BEYOND.ZBC HAS EDUCATIONAL RESOURCES IN THE FOLLOWING AREAS:1) GIRLS NEW PUBERTY SEEKS TO REDUCE THE LIKELIHOOD OF EARLY PUBERTY AND THEREFORE LIFETIME BREAST CANCER RISK. CURRENT MULTILINGUAL MATERIALS DIRECTED AT PARENTS AND CAREGIVERS INCLUDE MULTILINGUAL BOOKMARKS, INFOGRAPHICS, YOUTUBE VIDEOS AND MICROSITES. THESE ARE FREELY AVAILABLE ON ZBCS WEBSITE, AND SHARED THROUGH SOCIAL MEDIA, GOOGLE ADS, PARTNER ORGANIZATIONS AND LOCAL AND NATIONAL HEALTH FAIRS. A COLORING BOOK DIRECTED AT KIDS AGES 5+ IS AVAILABLE IN 5 LANGUAGES AND/OR CULTURES (ENGLISH, SPANISH, FRENCH, TAGALOG, AND AMERICAN INDIAN). IT IS SHARED DIGITALLY ON ZBCS WEBSITE AND PROMOTED THROUGH GOOGLE ADS; A HARD COPY ENGLISH-LANGUAGE COLORING BOOK WAS DISSEMINATED THROUGH SCHOOLS AND FEDERALLY QUALIFIED HEALTH CENTERS.2) HEALTHY FUTURES IS A NEW ACTIVITY PROGRAM FOR KIDS AGES 5-7 TO PROMOTE HEALTHY HABITS TO REDUCE THE LIKELIHOOD OF EARLY PUBERTY AND THEREFORE LIFETIME BREAST CANCER RISK. IN 2022, GIRLS, CAREGIVERS, AND TEACHERS WERE CONSULTED AND ENGAGED TO DEVELOP THE HEALTHY FUTURES ACTIVITY BOOK. THE ACTIVITY BOOK PROVIDES DIFFERENT AGE-APPROPRIATE ACTIVITIES IN FOUR CATEGORIES ASSOCIATED WITH REDUCING THE RISK OF EARLY PUBERTY AND BREAST CANCER LATER IN LIFE: MOVING MORE, EATING HEALTHY, GETTING ENOUGH SLEEP, AND FEELING BETTER (MANAGING STRESS). KIDS COMPLETE ONE ACTIVITY IN EACH OF FOUR AREAS TO RECEIVE A PATCH OR ZIPPER PULL AS A PRIZE. THE ACTIVITY BOOK WAS POSTED ON ZBCS WEBSITE AND SHARED WITH ZBCS AUDIENCES ON SOCIAL MEDIA AND IN EMAILS.3) 13 WAYS TO REDUCE YOUR RISK OF BREAST CANCER FOCUSES ON WAYS PEOPLE CAN REDUCE THEIR LIFETIME RISK OF BREAST CANCER THROUGH HEALTHY BEHAVIORS AND MODIFICATIONS OF THEIR ENVIRONMENTS. MATERIALS INCLUDE A WEBPAGE, POSTER, BROCHURES AND POSTCARDS. IN 2022, THE CAMPAIGN WAS SHARED DIGITALLY ON ZBCS WEBSITE, THROUGH GOOGLE ADS, AT ONLINE EVENTS, ON SOCIAL MEDIA. HARD COPY DISSEMINATION FOCUSED ON HEALTH CLINICS, HIGH SCHOOLS, SOCIAL SERVICES AGENCIES, AND ADULT SCHOOLS IN THE SAN FRANCISCO BAY AREA.4) GENERATIONS SEEKS TO REDUCE THE IMPACT OF ENDOCRINE DISRUPTING CHEMICALS ACROSS MULTIPLE GENERATIONS BY EDUCATING YOUNG ADULTS ABOUT HOW TO REDUCE EXPOSURE. IT WAS DEVELOPED IN COLLABORATION WITH THE CHDS ADVISORY GROUP WITH INPUT FROM CHDS RESEARCHERS. CAMPAIGN MATERIALS INCLUDE SIX EDUCATIONAL POSTERS AND A SECTION OF ZBCS WEBSITE. IN 2022, ZBC BEGAN SOLICITING THE INPUT OF SPANISH-SPEAKERS FOR THE ADAPTATION OF THE CAMPAIGN INTO SPANISH, TO BE CALLED GENERACIONES.5) SURVIVORSHIP FACTSHEETS: IN 2022, ZBC CONTINUED ADAPTING THE PATHWAYS STUDY NEWSLETTER ARTICLES PRODUCED IN COLLABORATION WITH BREAST CANCER SURVIVORS AND PATHWAYS RESEARCHERS

BRIDGING RESEARCHERS AND COMMUNITY MEMBERS:FROM THE OUTSET, ZBC DIFFERENTIATED ITSELF FROM OTHER BREAST CANCER ORGANIZATIONS THROUGH A UNIQUE ROLE IN RESEARCH. ZBC PARTNERS WITH SCIENTISTS FROM UNIVERSITIES AND CLINICAL ORGANIZATIONS ON MULTIPLE LEVELS TO REPRESENT THOSE AFFECTED BY THE DISEASE AND TO DISSEMINATE FINDINGS FROM STUDIES FOCUSED ON REDUCING THE RISK OF PRIMARY/RECURRENT BREAST CANCER AND IMPROVING QUALITY OF LIFE.1) PATHWAYS BREAST CANCER SURVIVORSHIP STUDY: PATHWAYS IS A PROSPECTIVE STUDY OF BREAST CANCER SURVIVORSHIP FOLLOWING A COHORT OF 4,504 WOMEN DIAGNOSED WITH INVASIVE BREAST CANCER IN THE KAISER PERMANENTE NORTHERN CALIFORNIA (KPNC) HEALTHCARE SYSTEM FROM 2006-2013. IN 2022, UNDER THE LEADERSHIP OF KPNCS DEPARTMENT OF RESEARCH AND THE ROSWELL PARK CANCER INSTITUTE, ZBC AND OTHER COLLABORATORS CONTINUED TO COLLECT AND ANALYZE DATA WITH INPUT FROM STUDY PARTICIPANTS, PUBLISH AND INFORMALLY SHARE RESEARCH RESULTS WITH MULTIPLE AUDIENCES, AND EXPAND THE RESEARCH, IN THE SECOND YEAR OF THE FOURTH ROUND OF FUNDING FROM THE NATIONAL CANCER INSTITUTE.ZBC CONTINUED TO FACILITATE AND MAINTAIN THE REFRESHED PATHWAYS STUDY COMMUNITY ADVISORY BOARD (CAB) WITH CONTINUED RESEARCH ADVISORY AIMS, AND EXPANDED OUTREACH AND DISSEMINATION GOALS, GIVEN THE STUDYS MATURITY AND THE INCREASING NUMBER OF FINDINGS OF INTEREST TO BREAST CANCER PATIENTS/SURVIVORS, CAREGIVERS, AND HEALTH CARE PROVIDERS. ZBC CONVENED THE CAB FOUR TIMES IN 2023; MEETINGS CONTINUED VIRTUALLY, IN KEEPING WITH KPNC POLICY. RESEARCHERS ROUTINELY SHARE STUDY IDEAS, DESIGNS, ISSUES, ANALYSIS APPROACHES, AND RESULTS, AND OFTEN RECEIVE USEFUL FEEDBACK FROM CAB MEMBERS.CAB MEMBERS COLLABORATED WITH ZBC AND KPNC STAFF, SCIENTISTS AND CLINICIANS TO WRITE ARTICLES FOR NEWSLETTERS MAILED TO ALL ACTIVE STUDY PARTICIPANTS (A SPANISH VERSION WAS MAILED TO THOSE WHO IDENTIFIED SPANISH AS THEIR PRIMARY LANGUAGE). IN 2022, PATHWAYS INTERVIEWERSNOTICED A DECLINE IN PARTICIPANT RESPONSIVENESS. AS PART OF RETENTION EFFORTS, THE NEWSLETTER ISSUE FOCUSED ON THANKING PARTICIPANTS FOR THEIR YEARS OF ANSWERING SURVEYS, ACKNOWLEDGING THEIR CONTRIBUTION TO SCIENCE THAT IS HELPING THEIR OWN AND FUTURE GENERATIONS, AND ENCOURAGING THEM TO CONTINUE TO PROVIDE THIS PRICELESS GIFT OF THEIR UNIQUE PERSPECTIVE AND EXPERIENCE. ZBC WORKED WITH THE CAB MEMBERS AND KPNC STAFF AND SCIENTISTS TO PLAN A NEW WEBINAR SERIES.2) BREAST CANCER AND THE ENVIRONMENT ACROSS GENERATIONS: ZBC CONTINUED TO ACT AS A COMMUNITY PARTNER ON A GRANT FROM THE CALIFORNIA BREAST CANCER RESEARCH PROGRAM (CBCRP) TO CHILD HEALTH AND DEVELOPMENT STUDIES (CHDS), TO COMMUNICATE THE ROLE OF ENVIRONMENTAL CHEMICALS IN BREAST CANCER. ZBC CONVENED AN ADVISORY GROUP TO TRANSLATE SCIENTIFIC EVIDENCE ABOUT THE ROLE OF ENDOCRINE DISRUPTING CHEMICALS ON BREAST CANCER RISK INTO MATERIALS THAT WILL ENGAGE AND INSPIRE HEALTHY CHANGES IN THE BEHAVIOR OF YOUNG ADULTS BEFORE PROCREATION. IN 2022, ZBC PRESENTED THE FINAL GENERATIONS CAMPAIGN TO A LARGER ADVISORY GROUP AND BEGAN ADAPTING THE CAMPAIGN INTO SPANISH, TO BE CALLED GENERACIONES.3) OTHER BREAST CANCER-RELATED RESEARCH: ZBC CONTINUED TO PARTNER WITH AND ADVISE SCIENTIFIC TEAMS ON RESEARCH PROJECTS RELEVANT TO ZBCS MISSION IN 2022. IN COLLABORATION WITH A STANFORD UNIVERSITY RESEARCHER, ZBC WAS THE ACTIVE ADVOCATE ON A SUCCESSFUL APPLICATION TO THE CBCRP TO FUND THE STUDY RISK FACTORS FOR SECOND BREAST CANCER IN RACIAL/ETHNIC MINORITY POPULATIONS. ZBC CONTINUED TO WORK WITH THIS RESEARCHER ON ADDITIONAL APPLICATIONS, INCLUDING DISPARITIES IN SECOND BREAST CANCER: ROLE OF INFLAMMATORY BIOMARKERS.IN 2022, ZBC CONTINUED WORK WITH THE PUBLIC HEALTH INSTITUTE (PHI) TEAM ON THE HORMONES AND MEAT: DOES BEEF UNDER-REGULATION GENERATE ESTROGENIC RESIDUES? (HAMBURGER) STUDY, PARTICIPATING IN JOINT DISCUSSIONS OF RESULTS WITH INVESTIGATORS OF THIS AND A PARALLEL STUDY, ALSO FUNDED BY THE CBCRP, AT THE UNIVERSITY OF CALIFORNIA-DAVIS, PROVIDING PERSPECTIVE ON ANALYSIS RELATED TO BREAST DEVELOPMENT AND ABOUT APPROACHES TO DISSEMINATION.ZBC STAFF HELPED TO EDIT ARTICLES ON THE RESULTS OF STUDIES FOR PUBLICATION IN PEER-REVIEWED JOURNALS FOR VARIOUS RESEARCH PROJECTS. ZBC JOINED THE ADVISORY COMMITTEE FOR THE CBCRP-FUNDED STUDY NONTARGET CHEMICAL ANALYSIS OF CALIFORNIA DRINKING WATER BEING CONDUCTED BY UNIVERSITY OF CALIFORNIA-DAVIS AND CONTINUES TO SERVE ON THE ADVISORY BOARD FOR THE NCI-FUNDED RESEARCH AT THE UC-SAN FRANCISCO (UCSF) TO DEVELOP, TEST, AND IMPLEMENT A PILOT CARDIAC REHABILITATION PROGRAM FOR CULTURALLY DIVERSE BREAST CANCER SURVIVORS SERVED BY UCSFS COMPREHENSIVE CANCER CENTER.