Military Health Research Foundation Inc

THE MILITARY HEALTH RESEARCH FOUNDATION(MHRF) IS A 501(C)(3) NONPROFIT ORGANIZATION DEDICATED TO THE ADVANCEMENT OF MILITARY MEDICAL RESEARCH TO BENEFIT THE HEALTH AND SAFETY OF THE MEN AND WOMEN OF THE UNITED STATES ARMED FORCES.

MEDICAL DEVICE DEVELOPMENT RESEARCH - MHRF CONDUCTS MEDICAL DEVICE RESEARCH FOR THE MILITARY PRIMARILY FOCUSED ON DEALING WITH TRAUMA, VASCULAR INJURY, RESUSCITATION AND OTHER COMBAT CARE TREATMENTS WHICH INCLUDE THE FOLLOWING PROJECTS: ENDOVASCULAR PERFUSION AUGMENTATION FOR CRITICAL CARE - MHRF HAS BEEN AWARDED A COOPERATIVE AGREEMENT FOR THE PERSONALIZED AND ADAPTIVE THERAPY FOR RESUSCITATION AFTER TRAUMA. THIS AGREEMENT PROVIDES FOR THE RESEARCH AND DEVELOPMENT OF INNOVATIVE PATIENT-CENTERED TECHNOLOGIES TO MAINTAIN PHYSIOLOGICAL EQUILIBRIUM IN AN EFFORT TO MINIMIZE PREVENTABLE DEATHS FOR CRITICALLY ILL WARFIGHTERS BY EMPLOYING PERSONALIZED, GOAL-DIRECTED PRECISION CRITICAL CARE SUPPORT IN WAYS THAT WERE NEVER BEFORE POSSIBLE. VENTRIGHT - MHRF HAS BEEN AWARDED A COOPERATIVE AGREEMENT FOR THE RESEARCH AND DEVELOPMENT OF A PORTABLE VENTILATION MONITORING OPTIMIZING CRITICAL CARE DEVICE FROM THE DEPARTMENT OF DEFENSE IN SUPPORT OF THE AIR FORCE MATERIEL COMMAND. THE OBJECTIVE OF THIS EFFORT IS TO DEVELOP: (A) A BATTERY-OPERATED DEVICE CAPABLE OF COLLECTING AND INTEGRATING VENTILATION AND PHYSIOLOGIC METRICS; (B) DIAGNOSTIC ALGORITHMS CAPABLE OF IDENTIFYING COMMON CRITICAL RESPIRATORY DISEASE STATES AND SUB-OPTIMAL VENTILATION; AND (C) INTEGRATION OF THE DEVICE WITH THE ALGORITHMS TO CREATE A ROBUST AND PORTABLE VENTILATION ANALYTICS MONITOR CAPABLE OF BATTLEFIELD DEPLOYMENT. EVAC - MHRF IS RESEARCHING THE DEVELOPMENT OF THE DESIGN OF A CLINICAL-GRADE EVAC CONTROLLER FOR PROLONGED WEANING TO PROVIDE PARTIAL FLOW WHICH WILL LEAD TO THE DEVELOPMENT OF HARDWARE AND SOFTWARE FOR TEST FIXTURES NEEDED FOR THE EVAC CONTROLLER MANUFACTURING, VERIFICATION AND VALIDATION TESTING AS WELL AS MANUFACTURING OF STERILE UNITS IN FINAL PACKAGING FOR THE VERIFICATION AND VALIDATION AND COMPLETION OF REGULATORY DOCUMENTATION FOR THE EVAC CONTROLLER.

LABORATORY AND ANIMAL RESEARCH - MHRF IS PERFORMING LABORATORY AND ANIMAL SCIENTIFIC RESEARCH AND EXPERIMENTS TO AID IN THE ADVANCEMENT OF MILITARY TECHNOLOGY AND MILITARY RESEARCH TO BENEFIT THE UNITED STATES ARMED FORCES WHICH INCLUDE THE FOLLOWING PROJECTS: UMD EPR - MHRF IS CONDUCTING WORK FOR THE UNIVERSITY OF MARYLAND, BALTIMORE CAMPUS TO INVESTIGATE EMERGENCY PRESERVATION AND RESUSCITATION (EPR) TECHNOLOGY IN THE CONTEXT OF AUTONOMOUS TRANSPORT. THE FIRST AIM IS TO CHARACTERIZE THE PHYSIOLOGIC RESPONSE TO EXTRA-CORPOREAL MEMBRANE OXYGENATION (ECMO) ACHIEVED EPR IN MODELS OF CONTROLLED YET CRITICAL PHYSIOLOGIC DERANGEMENT. THE SECOND AIM IS THE GENERATION OF CLOSED LOOP CONTROL ALGORITHMS TO AUTOMATE EMCO.SUCCOR COMBAT FOAM FOR LARGE BURN WOUNDS - MHRF LEAD A PROOF-OF-CONCEPT EVALUATION OF FINAL SUCCORTM FORMULATION COMPARED TO STANDARD OF CARE SILVER-CONTAINING DRESSINGS IN A COMBAT-RELEVANT ANIMAL MODEL OF INFECTED DEEP-PARTIAL THICKNESS THERMAL BURN WOUNDS HEALING IN THE ABSENCE OF GRAFTING. THE LARGE-ANIMAL SAFETY AND EFFICACY TESTING WAS PERFORMED WITH THE OREGON HEALTH & SCIENCE UNIVERSITY SCHOOL OF MEDICINE IN A LARGE-ANIMAL LABORATORY. EYE AID SYSTEM FOR ACUTE OCULAR THERAPIES - IN ALMOST ALL CASES, EFFICACY STUDIES SUPPORTING AN FDA REGULATORY SUBMISSION NEED TO BE PERFORMED UNDER GLP WITH A FINAL HUMAN-USABLE CGMP DEVICE. EARLIER-STAGE EFFICACY TESTING PRIOR TO LOCKING IN CGMP DEVICE PRODUCTION CAN HELP REDUCE REGULATORY AND PROGRAMMATIC RISK. MHRF PERFORMED ANIMAL EFFICACY STUDIES WITH OREGON HEALTH & SCIENCE UNIVERSITY TO GENERATE PERFORMANCE DATA AND REDUCE THE RISKS. MITOCHONDRIA - THERE ARE SEVERAL DISEASES INCLUDING TRAUMA AND HEMORRHAGE THAT ADVERSELY AFFECT THE MITOCHONDRIA OF THE BODY. MHRF IS WORKING WITH AN INVESTIGATOR FROM THE UNIVERSITY OF UTAH TO STUDY THE USE OF ELAMIPRETIDE, AS A MOLECULE TO REDUCE COMPLICATIONS ASSOCIATED WITH THE USE OF RESUSCITATIVE ENDOVASCULAR BALLOON OCCLUSION OF THE AORTA (REBOA) IN A PIG MODEL OF SEVERE BLOOD LOSS. THIS EXPERIMENT WILL DEMONSTRATE THAT ELAMIPRETIDE CAN PREVENT COMPLICATIONS COMMONLY OBSERVED AFTER USING REBOA CATHETERS.

OTHER PROGRAM SERVICES - MHRF ALSO PROVIDES ENTERPRISE, PROGRAM, AND PROJECT LEVEL RESEARCH ADMINISTRATION AND PROVIDES SOLUTIONS TO SPECIFIC TASKINGS SUCH AS RESEARCH PROCESS CONSULTING, STAFFING SUPPORT, AND CLINICAL TRIALS WHICH INCLUDE THE FOLLOWING PROJECTS: PE SYSTEMS CONDUCTS ACQUISITION AND PROTOTYPING SUPPORT FOR THE UNITED STATES AIR FORCE. MHRF PROVIDES A PROJECT LEVEL SUBJECT MATTER EXPERT THAT SERVES AT THE LIFE CYCLE MANAGEMENT GROUP FOR THE HUMAN SYSTEMS DIVISION.CDC EAGLE GLOBAL SCIENTIFIC IS A LIFE SCIENCES COMPANY THAT PROVIDES RESEARCH, DEVELOPMENT, AND PERSONNEL SUPPORT TO MANY FEDERAL AGENCIES. MHRF PROVIDES AN EPIDEMIOLOGIST THAT WORKS DIRECTLY AT THE CENTERS FOR DISEASE CONTROL. ZEISS CRADA: MHRF PROVIDES A CLINICAL RESEARCH ASSISTANT WHO WORKS AT THE REFRACTIVE SURGERY CENTER LOCATED IN THE WILFORD HALL AMBULATORY SURGICAL CENTER AT LACKLAND AIR FORCE BASE.