Wellcome Leap Inc

DELTA TISSUE: INTEGRATED PLATFORMS FOR PREDICTING CHANGES IN TISSUE STATE, IS A $55 MILLION EFFORT THAT BRINGS EXPERTS IN THE LIFE SCIENCES AND ENGINEERING TOGETHER FROM ACROSS UNIVERSITIES, FOUNDATIONS, AND THE PRIVATE SECTOR TO DEVELOP A PLATFORM THAT CAN PROFILE TISSUE STATES AND PREDICT TRANSITIONS BETWEEN STATES IN WAYS THAT ARE IMPOSSIBLE TODAY.DELTA TISSUE AIMS TO BUILD NEW PLATFORMS MULTISCALE, MULTIMODAL, AND WIDELY ACCESSIBLE THAT ALLOW US TO PREDICT HOW TISSUES WILL CHANGE IN THE FUTURE WITH THE FIDELITY NEEDED TO INTERVENE IN THE PRESENT A 'TISSUE TIME MACHINE'.

MULTI-CHANNEL PSYCH (MCPSYCH) AIMS TO DEVELOP AN INTEGRATED MODEL OF ANHEDONIC DEPRESSION THAT CAPTURES BOTH INTERNAL BIOLOGICAL FACTORS AND EXTERNALLY-MANIFESTED, QUANTIFIABLE MEASURES. THE PROGRAM ALSO SEEKS TO REVEAL BIOLOGICAL MECHANISMS OF ANHEDONIA BY SYNCHRONIZING INVESTIGATIONS ACROSS GENES, MOLECULES, CELLS, ANIMAL MODELS, AND HUMANS.MCPSYCH HAS THE GOAL OF DOUBLING THE NUMBER OF PEOPLE WHO RECEIVE AN EFFECTIVE TREATMENT ON THE FIRST TRY. IN ADDITION, THE PROGRAM SEEKS TO REVEAL MECHANISTIC UNDERSTANDING SUFFICIENT TO IDENTIFY EFFECTIVE TREATMENTS FOR HALF OF NON-RESPONSIVE PATIENTS AND HAVE THE SAME IMPACT ON THE SURVIVABILITY OF SEVERE, TREATMENT-RESISTANT DEPRESSION THAT ADVANCES IN DIAGNOSTICS AND TREATMENT HAVE HAD ON THE SURVIVABILITY OF CERTAIN CANCERS. NAMELY, THAT IN THE FUTURE, IT WILL BE POSSIBLE TO HELP 85% OF PEOPLE SURVIVE THEIR SUICIDAL ANHEDONIC DEPRESSION FOR AT LEAST 5 YEARS AND PERHAPS A FULL LIFETIME AFTER DIAGNOSIS.

THE FIRST 1000 DAYS (1KD) IS A $45 MILLION PROGRAM THAT BRINGS TOGETHER EXPERTS IN THE LIFE SCIENCES, ENGINEERING, AND COMPUTER SCIENCE FROM ACROSS UNIVERSITIES, NONPROFITS, AND THE PRIVATE SECTOR TO DEVELOP SCALABLE MEASUREMENT METHODS AND MODELS TO PREDICT AND PROMOTE HEALTHY BRAIN DEVELOPMENT IN INFANTS.THE FIRST THOUSAND DAYS CAN MAKE ALL THE DIFFERENCE TO A CHILD'S START IN LIFE, PERHAPS MORE SO THAN WE EVER UNDERSTOOD BEFORE. IN THIS EARLY PERIOD, WE DEVELOP CRITICAL COGNITIVE ABILITIES SUCH AS EXECUTIVE FUNCTION (EF) AND SELF-REGULATION. BY THE END OF THE FIRST THOUSAND DAYS, A CHILD'S INDIVIDUAL EF PERFORMANCE CHANGES THEIR ODDS OF DEALING SUCCESSFULLY WITH OPPORTUNITIES AND OBSTACLES THEY FACE IN LIFE. CHILDREN WITH UNDERDEVELOPED EF AT AGE 3 REPRESENT ABOUT 20 PERCENT OF THE POPULATION, BUT MAKE UP NEARLY 80 PERCENT OF ADULTS WHO ARE LIKELY TO REQUIRE SOME FORM OF SOCIETAL OR ECONOMIC ASSISTANCE.

THE HUMAN ORGANS, PHYSIOLOGY, AND ENGINEERING (HOPE) PROGRAM IS A $50 MILLION EFFORT THAT BRINGS EXPERTS IN THE LIFE SCIENCES AND ENGINEERING TOGETHER FROM ACROSS UNIVERSITIES, FOUNDATIONS, AND COMPANIES TO DEVELOP HUMAN TISSUES, ORGANOIDS, ORGANS, AND PLATFORMS THAT ACCELERATE AND SCALE NEW TREATMENTS.FOCUSED ON REPLICATION OF COMPLEX HUMAN ORGANS AND IMMUNE SYSTEM INTERACTIONS, IF SUCCESSFUL, THE HOPE PROGRAM WOULD HAVE ENORMOUS IMPLICATIONS FOR ADVANCING CANCER, AUTOIMMUNE, AND INFECTIOUS DISEASE INTERVENTIONS, AND, EVENTUALLY, TO BIOENGINEERED, SCALABLY-PRODUCED, IMMUNE-TOLERANT ORGANS FOR TRANSPLANTATION.