Cancer Prevention Initiative Inc

CANCER PREVENTION INITIATIVE, INC. (CPI) IS A NONPROFIT CORPORATION WHOSE MISSION IS TO ACCELERATE THE DISCOVERY AND DEVELOPMENT OF NEW MEDICINES THAT PREVENT CANCER.

IN 2021, THE CANCER PREVENTION INITIATIVE (CPI) PROGRAMS HAVE PROGRESSED AND CPI CONTINUES TO GROW AND DEVELOP. CPI'S RESEARCH GRANT RECIPIENTS HAVE CONTINUED TO ADVANCE US TOWARDS UNDERSTANDING AND PREVENTING INHERITED CANCERS. A NEWLY FUNDED PROJECT WITH CLEVELAND CLINIC SEEKS TO IDENTIFY PROTEINS UNIQUELY AND HIGHLY EXPRESSED IN BREAST CANCER OF BRCA1 MUTATION CARRIERS. IDENTIFICATION OF THESE UNIQUE PROTEINS IS AN IMPORTANT LINK FOR DEVELOPING PREVENTATIVE VACCINES. ALSO NEWLY FUNDED IS A PROJECT WITH MEMORIAL SLOAN KETTERING CANCER CENTER TO GENERATE A ROBUST CELLULAR ASSAY THAT WOULD ALLOW FOR THE SCREENING OF HUNDREDS OF COMPOUNDS TO IDENTIFY DETERMINANTS OF LOSS OF HETEROZYGOSITY (LOH) OF BRCA GENES. LOH IS A MAJOR DRIVER IN CANCER INITIATION, AND DISCOVERY OF COMPOUNDS THAT CAUSE LOH CAN BE KEY FOR PREVENTION DISCOVERIES. ONGOING PROJECTS INCLUDE HARVARD'S BETH ISRAEL DEACONESS MEDICAL CENTER WHERE THEY ARE WORKING TO IDENTIFY CANCER RISK PREDICTORS IN THE REPRODUCTIVE EPITHELIUM IN BRCA MUTATION CARRIERS. A PROJECT AT CITY OF HOPE IS PROGRESSING TO REPURPOSE A SAFE, FDA APPROVED ANTI-PARASITIC DRUG THAT HAS GREAT PROMISE FOR REDUCING BREAST CANCER GROWTH. REPURPOSING DRUGS IS A SAFE WAY TO BRING THERAPIES TO PATIENTS QUICKLY. RELATED TO THIS IS A NEED FOR WAYS TO EVALUATE KNOWN DRUGS FOR NEW PURPOSES. A TEAM AT THE UNIVERSITY OF TORONTO IS DEVELOPING A TEST TO SCREEN FOR DRUGS THAT CAN RESTORE NORMAL BRCA1 FUNCTION TO BRCA1 DEFICIENT CELLS. AN INTERNATIONAL COLLABORATION HAS CO-DEVELOPED A CANDIDATE VACCINE FOR THE PREVENTION OF TRIPLE NEGATIVE BREAST CANCERS IN PATIENTS WHO HAVE INHERITED A BRCA1 MUTATION. NEW GRANTS WERE MADE IN 2021 TOTALED $480,000. THIS AMOUNT IS OFFSET BY THE RETURN OF $264,764 FROM A 2017 GRANT WHERE THE GRANTEE WAS NOT ABLE TO COMPLETE THEIR CONTRACTED PROJECT. THE GRANT EXPENSES FOR 2021 ARE $480,000 - 264,764 = $215,236.

EDUCATION AND COMMUNITY ENGAGEMENT PROGRAMS: AS WE MOVE CLOSER TO OUR GOAL OF ERADICATING ALL CANCERS THROUGH PREVENTATIVE MEDICINES, WE BELIEVE THAT EDUCATING THE PUBLIC AND RAISING AWARENESS ABOUT INHERITED CANCER SYNDROMES WILL INSPIRE MORE INDIVIDUALS TO TAKE PROACTIVE, LIFE-SAVING PREVENTIVE MEASURES. ONE OF THE GOALS IS TO ENHANCE THE SCIENTIFIC REACH OF THE ORGANIZATION AND RAISE AWARENESS ON CANCER PREVENTION TO A BROADER AUDIENCE OF PATIENTS, ADVOCATES AND DONORS. THUS, REGULAR UPDATES ON SCIENTIFIC AND MEDICAL RESEARCH ADVANCES, RECENT CLINICAL TRIALS, AND INTERVIEWS WITH EXPERTS IN CANCER PREVENTION ARE PUBLISHED ON WEB-BASED PLATFORMS.