Chan Zuckerberg Biohub Inc

CONDUCT CUTTING EDGE MEDICAL RESEARCH

IN 2022 THE CHAN ZUCKERBERG BIOHUB, INC. ("CZ BIOHUB") CELEBRATED ITS 6TH ANNIVERSARY AS A MEDICAL RESEARCH ORGANIZATION. CONSISTENT WITH OUR MISSION, WE CONTINUED TO FOCUS ON LARGE-SCALE SCIENTIFIC INITIATIVES THAT WE ARE UNIQUELY POSITIONED TO SUPPORT AND EXECUTE, EACH ON A MULTI-YEAR TIMELINE:1. INTRAMURAL RESEARCH PROJECTS LED BY CZ BIOHUB RESEARCHERS THAT EMPHASIZE BASIC SCIENCE, IN TWO MAIN AREAS:A. QUANTITATIVE CELL SCIENCEB. INFECTIOUS DISEASE2. PROGRAMS SUPPORTING SCIENTISTS AND PHYSICIANS AT OUR INSTITUTIONS UNIVERSITIES (STANFORD UNIVERSITY; UC SAN FRANCISCO; UC BERKELEY) THROUGH THE CZ BIOHUB INVESTIGATOR PROGRAM, PHYSICIAN-SCIENTIST FELLOWSHIP PROGRAM, AND COLLABORATIVE POSTDOCTORAL FELLOWSHIP PROGRAM.HIGHLIGHTS- IN MARCH 2022, THE PAPER DESCRIBING OPENCELL - AN OPEN-SOURCE, PROTEOME-SCALE COLLECTION OF PROTEIN LOCALIZATION AND INTERACTION MEASUREMENTS IN HUMAN CELLS - WAS PUBLISHED IN SCIENCE, AND HAS SINCE BEEN DOWNLOADED MORE THAN 31,000 TIMES. THE OPENCELL'S ALTMETRIC SCORE IS 433, PLACING IT IN THE TOP 5% OF ALL RESEARCH OUTPUTS TRACKED BY ALTMETRIC. FOR THIS ACHIEVEMENT AND HIS LARGER BODY OF WORK, CZ BIOHUB SF SCIENTIST MANUEL LEONETTI WON THE INNOVATION IN RESEARCH AWARD FROM THE AMERICAN SOCIETY FOR CELL BIOLOGY, A DISTINCTION THAT "RECOGNIZES EARLY AND MID-CAREER SCIENTISTS FOR THEIR NEW AND INNOVATIVE RESEARCH IN CELL BIOLOGY."- THE TABULA SAPIENS, A SINGLE-CELL ATLAS OF MORE THAN 400 HUMAN CELL TYPES BASED ON ANALYSIS OF NEARLY 500,000 CELLS FROM MULTIPLE ORGANS, WAS PUBLISHED IN SCIENCE IN MAY 2022. THE PAPER HAS SINCE BEEN DOWNLOADED NEARLY 120,000 TIMES, AND HAS AN ALTMETRIC SCORE OF 1158, PLACING IT IN THE TOP 5% OF ALL RESEARCH OUTPUTS TRACKED BY ALTMETRIC.- OUR RAPID RESPONSE TEAM TRAINED VISITING SCIENTIFIC TEAMS FROM ZAMBIA, PAKISTAN, CAMBODIA, AND BANGLADESH IN METAGENOMIC NEXT-GENERATION SEQUENCING TECHNIQUES AND THE USE OF CZ ID, AN OPEN-SOURCE WEB PORTAL AND DATABASE TO TRACK AND IDENTIFY PATHOGENS IN THEIR RESPECTIVE COUNTRIES AND RESPOND TO INFECTIOUS DISEASE OUTBREAKS.- IN JANUARY 2022, WE ANNOUNCED OUR SECOND COHORT OF CZ BIOHUB INVESTIGATORS, 86 SCIENTISTS WORKING IN DIVERSE FIELDS AT STANFORD, UCSF, AND UC BERKELEY SUPPORTED BY UNRESTRICTED RESEARCH GRANTS FROM THE BIOHUB.- THROUGH OUR COLLABORATIVE POSTDOCTORAL FELLOWSHIP PROGRAM, WE SUPPORTED INTERDISCIPLINARY, COLLABORATIVE RESEARCH BY SEVEN FELLOWS IN LABS AT ALL THREE OF OUR PARTNER UNIVERSITIES. OUR PHYSICIAN-SCIENTIST FELLOWSHIP PROGRAM TRAINED SIX PHYSICIANS AT UCSF AND STANFORD UNIVERSITY IN BIOMEDICAL RESEARCH TECHNIQUES (BOTH LABORATORY AND COMPUTATIONAL) THROUGH AN IMMERSIVE, HANDS-ON EXPERIENCE.