New York Structural Biology Center Inc

Organization Overview

New York Structural Biology Center Inc is located in New York, NY. The organization was established in 1999. According to its NTEE Classification (U50) the organization is classified as: Biological & Life Sciences, under the broad grouping of Science & Technology and related organizations. As of 12/2022, New York Structural Biology Center Inc employed 71 individuals. This organization is an independent organization and not affiliated with a larger national or regional group of organizations. New York Structural Biology Center Inc is a 501(c)(3) and as such, is described as a "Charitable or Religous organization or a private foundation" by the IRS.

For the year ending 12/2022, New York Structural Biology Center Inc generated $28.7m in total revenue. This represents relatively stable growth, over the past 7 years the organization has increased revenue by an average of 4.0% each year. All expenses for the organization totaled $23.9m during the year ending 12/2022. While expenses have increased by 9.4% per year over the past 7 years. They've been increasing with an increasing level of total revenue. You can explore the organizations financials more deeply in the financial statements section below.

Mission & Program ActivityExcerpts From the 990 Filing

TAX YEAR

2022

Describe the Organization's Mission:

Part 3 - Line 1

SEE SCHEDULE O.TO OPERATE A STATE-OF-THE-ART FACILITY FOR ADVANCE RESEARCH IN STRUCTURAL BIOLOGY AND PROVIDE ADVANCED RESOURCES TO THE FACULTY OF ITS PARTICIPATING MEMBER INSTITUTIONS AND RESEARCHERS FROM THE NATIONAL COMMUNITY.

Describe the Organization's Program Activity:

Part 3 - Line 4a

RESEARCH CONDUCTED AT THE SIMONS ELECTRON MICROSCOPY CENTER (SEMC) IS AIMED AT DETERMINING THE STRUCTURE OF MACROMOLECULES TO HELP UNDERSTAND THEIR FUNCTION. THE FACILITY HAS 12 TRANSMISSION ELECTRON MICROSCOPES, 2 DUAL-BEAM FOCUSED ION BEAM SCANNING ELECTRON MICROSCOPES, AS WELL AS ANCILLARY EQUIPMENT FOR CRYOEM SAMPLE PREPARATION. SEMC IS ACTIVELY SERVING OVER 250 USERS FROM NYSBC'S NINE MEMBER INSTITUTIONS AS WELL AS USERS FROM THE NATIONAL COMMUNITY THROUGH NYSBC AND NIH-FUNDED CENTERS (NATIONAL CENTER FOR CRYOEM ACCESS AND TRAINING AND NATIONAL CENTER FOR IN-SITU TOMOGRAPHIC ULTRAMICROSCOPY). SEMC DEVELOPS OPEN-SOURCE TECHNOLOGIES TO ACCELERATE CRYOEM WORKFLOWS FROM SAMPLE PREPARATION TO STRUCTURE DETERMINATION THROUGH ITS SIMONS FOUNDATION INITIATIVES (SIMONS RESOURCE FOR AUTOMATED MOLECULAR MICROSCOPY AND SIMONS MACHINE LEARNING CENTER). SEMC ALSO PROVIDES EXTENSIVE TRAINING TO MEMBERS OF THE COMMUNITY THROUGH WORKSHOPS, COURSES, AND OTHER TRAINING SESSIONS. IN SEVERAL PROJECTS, SEMC STAFF HAS BEEN INVOLVED EXTENSIVELY AS COLLABORATORS DEVELOPING NEW MACHINE LEARNING ALGORITHMS AND SOFTWARE FOR AUTOMATING CRYOEM, AND CONTRIBUTING TO SOLVING THE STRUCTURES OF: CRISPR-CAS COMPLEXES, ION CHANNELS, GPCRS, AND MANY DRUG TARGETS, E.G., AGAINST DISEASES LIKE COVID-19. A TOTAL OF 78 PEER-REVIEWED SCIENTIFIC PUBLICATIONS ACKNOWLEDGED SEMC SUPPORT IN 2022.


THE RESEARCH SERVICES LABORATORY AT NYSBC IS A TEAM OF EXPERT SCIENTISTS THAT PERFORMS FEE-FOR-SERVICE PROTEIN STRUCTURE DETERMINATION AND PROTEIN PRODUCTION SERVICES FOR EXTERNAL CLIENTS. IN ADDITION, THEY ALSO RECEIVE FUNDING THROUGH COLLABORATIVE RESEARCH PROJECTS WITH ACADEMIC AND GOVERNMENT LABORATORIES. THEY COMPLETED THE THIRD YEAR OF A FIVE YEAR NIAID CONTRACT USING STRUCTURAL BIOLOGY TO INVESTIGATE THE ETIOLOGIC AGENT FOR LYME DISEASE, BORRELIA BURGDORFERI, TO DESIGN A VACCINE OR DISCOVER ANTIBODY THERAPEUTICS AGAINST LYME DISEASE. IN ADDITION, THEY PARTICIPATED IN STRUCTURAL BIOLOGY RESEARCH PROJECTS WITH COLLABORATORS AT RUTGERS UNIVERSITY INVESTIGATING RICIN AND SHIGA TOXINS TO RATIONALLY DESIGN BETTER INHIBITORS AGAINST THESE TWO TOXINS.


NYSBC PROVIDES ACCESS TO HIGH-FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO FACULTY FROM ITS NINE MEMBER INSTITUTIONS. THE NMR FACILITY INSTRUMENTATION INCLUDES NINE NMR SPECTROMETERS THAT GENERALLY OPERATE 24 HRS/DAY, 7 DAYS/WEEK. IN 2022, EACH SPECTROMETER WAS AVAILABLE, ON AVERAGE, 328 DAYS. THESE RESOURCES ALLOW RESEARCHERS TO DETERMINE THE STRUCTURE OF PROTEINS IN SOLUTION AND IN SOLID STATE TO ATOMIC RESOLUTION, DATA THAT PROVIDES INSIGHT INTO THE FUNCTIONAL PROPERTIES OF THE PROTEINS. IN 2022, GROUP MEMBERS FROM THE LABORATORIES OF 19 AFFILIATED PRINCIPAL INVESTIGATORS MADE USE OF THESE INSTRUMENTS. DATA COLLECTED WITH THESE INSTRUMENTS PRODUCED 22 PUBLICATIONS IN PEER-REVIEWED SCIENTIFIC PUBLICATIONS. THE CENTER OPERATES THE CENTER ON MOLECULAR DYNAMICS BY NMR (COMD/NMR), A BIOMEDICAL TECHNOLOGY RESEARCH RESOURCE SUPPORTED BY U.S. NATIONAL INSTITUTES OF HEALTH GRANTS P41 GM118302 / RM1 GM145397 AND LOCATED AT NYSBC. THE MISSION OF COMD-NMR IS TO MAKE AVAILABLE TO THE BIOLOGICAL RESEARCH COMMUNITY ADVANCED NMR SPECTROSCOPIC AND COMPUTATIONAL METHODS FOR CHARACTERIZING PROTEIN AND NUCLEIC ACID CONFORMATIONAL DYNAMICS IN BIOLOGICAL PROCESSES.


NYSBC HAS MAINTAINED X-RAY CRYSTALLOGRAPHY RESOURCES AT BROOKHAVEN NATIONAL LABORATORY (BNL) SINCE 2003. NYSBC HAS DEVELOPED AND OPERATES BEAMLINE 19ID-NYX AT THE NATIONAL SYNCHROTRON LIGHT SOURCE II (NSLS-II). NYX PROVIDES THE NYSBC MEMBER INSTITUTIONS AND ASSOCIATED INVESTIGATORS WITH ACCESS TO SYNCHROTRON RADIATION AND INSTRUMENTATION NECESSARY FOR COLLECTING CRYSTALLOGRAPHIC DATA ON BIOLOGICAL MACROMOLECULES. NYX HAS PERFORMED TECHNICAL AND SCIENTIFIC COMMISSIONING AND STARTED USER OPERATIONS IN THE SPRING OF 2019. THE PRIMARY ACCOMPLISHMENTS OF THE BEAMLINE PROGRAM FOR 2022 WERE UPGRADES TO AUTOMATION AND SOFTWARE AND SUPPORTING USER EXPERIMENTS.


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Board, Officers & Key Employees

Name (title)Compensation
Dr David Hirsh
Chairman
$0
Dr Frederick Maxfield
Secretary
$0
Dr Timothy P O'connor
Treasurer
$0
Dr Steven C Almo
Board Member
$0
Dr David Cowburn
Board Member
$0
Dr Tony M Liss
Board Member
$0

Outside Vendors & Contractors

Vendor Name (Service)Compensation
Fei Company
Scientific Equipment Servicer
$1,543,238
Fresh Meadow Chiller Associates Llc
Construction Services
$1,015,564
Bruker Biospin Corporation
Scientific Equipment Servicer
$341,426
International Protective Service Agency
Security Staffing
$116,714
View All Vendors

Financial Statements

Statement of Revenue
Federated campaigns$0
Membership dues$0
Fundraising events$0
Related organizations$0
Government grants $13,722,326
All other contributions, gifts, grants, and similar amounts not included above$14,038,759
Noncash contributions included in lines 1a–1f $0
Total Revenue from Contributions, Gifts, Grants & Similar$27,761,085
Total Program Service Revenue$0
Investment income $239,523
Tax Exempt Bond Proceeds $0
Royalties $0
Net Rental Income $0
Net Gain/Loss on Asset Sales $0
Net Income from Fundraising Events $0
Net Income from Gaming Activities $0
Net Income from Sales of Inventory $0
Miscellaneous Revenue$0
Total Revenue $28,684,129

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