Blueprint Biosecurity

THE MISSION OF THE ORGANIZATION IS TO ACHIEVE BREAKTHROUGHS IN HUMANITY`S CAPABILITY TO PREVENT, MILITIGATE, AND SUPPRESS PANDEMICS.

GENERAL PROGRAM - BLUEPRINT BIOSECURITY'S GENERAL PROGRAM BROADLY SUPPORTS OUR MISSION TO MITIGATE THE RISK OF PANDEMICS THROUGH DEVELOPING ACTIONABLE PLANS, STAKEHOLDER ENGAGEMENT, AND EFFECTIVE EXECUTION OF OUR INITIATIVES. WE SUPPORT AND CONVENE CONFERENCES, WORKSHOPS, AND OTHER PUBLIC EVENTS TO SHARE OUR RESEARCH AND STRATEGIES FOR PANDEMIC PREVENTION. WE ENGAGE WITH AND EDUCATE KEY STAKEHOLDERS, INCLUDING GOVERNMENTS, RESEARCHERS, THINK TANKS, AND PHILANTHROPISTS, TO BUILD STRONG NETWORKS ESSENTIAL FOR EFFECTIVE PANDEMIC PREVENTION. OUR FOCUS IS ON DEVELOPING COLLABORATIVE RELATIONSHIPS THAT FACILITATE THE IMPLEMENTATION OF COMPREHENSIVE BIOSECURITY MEASURES. OUR MULTIDISCIPLINARY TEAMS WORK COLLABORATIVELY TO EXECUTE OUR STRATEGIC INITIATIVES, WHICH INCLUDE CONDUCTING RESEARCH, DEVELOPING ACTIONABLE PLANS, FUNDING STUDIES, AND IMPLEMENTING PILOT PROGRAMS. THROUGH THESE ACTIVITIES, BLUEPRINT BIOSECURITY AIMS TO CREATE A RESILIENT FRAMEWORK CAPABLE OF PREVENTING AND MITIGATING THE IMPACTS OF FUTURE PANDEMICS, ULTIMATELY LEADING TO A SAFER AND MORE PREPARED WORLD. BY DECEMBER 2023, WE CONDUCTED ABOUT 50 EXPERT INTERVIEWS ACROSS A WIDE SPECTRUM OF THE BIOSECURITY FIELD. THIS RESULTED IN A DATABASE OF OVER 200 IDEAS FOR INTERVENTIONS CATEGORIZED ACROSS EIGHT CATEGORIES. BASED ON OUR REVIEW OF THE FINDINGS AND ASSESSMENT OF OUR ORGANIZATION'S STRENGTHS AND WHERE OTHER ORGANIZATIONS ARE FOCUSING, WE DECIDED TO INITIALLY PRIORITIZE RESEARCH ON PATHOGEN TRANSMISSION SUPPRESSION, SPECIFICALLY THE SET OF INTERVENTIONS THAT ARE EFFECTIVE AGAINST A BROAD RANGE OF PATHOGENS AND SHOW PROMISE FOR MAKING IT MUCH MORE DIFFICULT FOR HIGHLY INFECTIOUS RESPIRATORY PATHOGENS TO SPREAD. THIS WORK HAS TWO PRIMARY SUB-COMPONENTS: BUILT ENVIRONMENT TRANSMISSION SUPPRESSION AND THE NEXT GENERATION OF PERSONAL PROTECTIVE EQUIPMENT.

OTHER PROGRAMS

FAR UVC - OUR MAIN FAR-UVC PROJECT IS ASSESSING FAR-UVC AS A TOOL FOR PANDEMIC PREVENTION AND WRITING A ROADMAP FOR ACCELERATING ITS RESEARCH, DEVELOPMENT, AND DEPLOYMENT. ADDITIONALLY, WE HAVE CONDUCTED MODELING OF THE EFFICACY OF FAR-UVC, SUPPORTED RESEARCH ON EYE SAFETY, AND SUPPORTED CONFERENCES AND WORKSHOPS ON FAR-UVC. OUR UPCOMING FAR-UVC ROADMAP, WHICH WE CALL A 'BLUEPRINT,' TACKLES THE PROMISE AND COMPLEXITIES OF USING FAR-UVC TO CLEAN THE AIR OF INFECTIOUS PATHOGENS. IT INCLUDES EXTENSIVE REVIEWS AND ANALYSES OF: DISINFECTION EFFICACY AND TRANSMISSION SUPPRESSION, SAFETY AND OTHER POSSIBLE UNINTENDED CONSEQUENCES, REGULATIONS & STANDARDS RELEVANT TO THE USE OF FAR-UVC, CURRENT AND FUTURE LAMP TECHNOLOGY, AND A COST-BENEFIT ANALYSIS. WE GROUND THIS ANALYSIS WITH COMPREHENSIVE LITERATURE REVIEWS, INTERVIEWS WITH EXPERTS, AND ORIGINAL MODELING. OUR ROADMAP WILL OUTLINE ESSENTIAL STEPS FOR THE DEVELOPMENT OF FAR-UVC AS A TOOL FOR SAFER INDOOR SPACES AND PANDEMIC PREVENTION. THE ULTIMATE GOAL OF A BLUEPRINT IS TO ELEVATE OUR COLLECTIVE AMBITIONS AND SHOW HOW EVERYONE- FROM RESEARCHERS, ENTREPRENEURS, REGULATORS, LEGISLATORS, GOVERNMENTS, PHILANTHROPISTS, AND MEMBERS OF CIVIL SOCIETY- CAN CONTRIBUTE TO PREVENTING THE NEXT PANDEMIC. TO SUPPORT RESEARCH ON EYE SAFETY, WE LAUNCHED A REQUEST FOR PROPOSALS (RFP) TO IDENTIFY AND FUND GRANT OPPORTUNITIES FOR FURTHER UV-C EYE SAFETY STUDIES. CURRENT RESEARCH, PRIMARILY FOCUSED ON WAVELENGTHS AT 222 NM, SHOWS FAR-UVC IS MOSTLY ABSORBED BY THE STRATUM CORNEUM IN THE CASE OF SKIN, AND IN THE CASE OF EYES, THE SUPERFICIAL EPITHELIAL CELLS OF THE CORNEA AND POTENTIALLY THE TEAR FILM. THROUGH OUR GRANTS, WE SEEK TO UNDERSTAND WHAT (IF ANY) LEVEL OF EYE EXPOSURE TO FAR-UVC LEADS TO SUBJECTIVE OCULAR DISCOMFORT AND THE POTENTIAL METHODS OF MEASURING AND UNDERSTANDING OCULAR IRRITATION. ANY IDENTIFIED IRRITATION BIOMARKERS CAN THEN BE USED TO 1) STUDY OCULAR IRRITATION AND 2) DETERMINE THE HIGHEST FAR-UVC DOSE FOR PATHOGEN STERILIZATION THAT DOES NOT INDUCE OCULAR IRRITATION.

BUILT ENVIROMENT TRANSMISSION SUPPRESSION - OUR PHYSICAL ENVIRONMENTS - FROM AIRPORTS TO CHILDCARE CENTERS, FACTORIES, AND SCHOOLS - PLAY A MAJOR ROLE IN THE SPREAD OF PATHOGENS. BUT THERE ARE MANY FUNDAMENTAL OPEN QUESTIONS ABOUT INDOOR TRANSMISSION THAT LEAVE US VULNERABLE TO NEW PANDEMICS: IN WHICH SPECIFIC BUILT ENVIRONMENTS DO HIGHLY CONTAGIOUS DISEASES CURRENTLY SPREAD MOST EASILY? WHICH NASCENT TECHNOLOGIES SHOW THE MOST PROMISE FOR REDUCING INDOOR PATHOGEN TRANSMISSION? WHAT UPGRADES ARE MOST FEASIBLE IN THE PLACES WHERE THEY'D MAKE THE BIGGEST DIFFERENCE? OUR BUILT ENVIRONMENT TRANSMISSION SUPPRESSION PROJECT EXPLORES THESE QUESTIONS IN DEPTH. WE'RE CURRENTLY EVALUATING A WIDE RANGE OF TECHNOLOGIES AND INTERVENTIONS THAT HAVE THE POTENTIAL TO SIGNIFICANTLY REDUCE INDOOR PATHOGEN TRANSMISSION AND DEVELOPING MODELS TO UNDERSTAND WHICH SPECIFIC ENVIRONMENTS BEAR THE GREATEST BURDEN OF TRANSMISSION. ONCE THESE RESULTS ARE IN, WE'LL PUBLISH OUR INVESTIGATIONS AND WRITE A STRATEGIC ROADMAP FOR HOW INTERESTED STAKEHOLDERS CAN HELP ACCELERATE THE MOST PROMISING SOLUTIONS. THIS INVESTIGATION WILL SET US UP FOR A LARGER PROJECT THAT RIGOROUSLY TESTS THESE INITIAL FINDINGS, GOES DEEPER INTO THE MOST PROMISING INTERVENTIONS AND COMBINATIONS OF INTERVENTIONS, INVESTIGATES HOW FEASIBLE IMPLEMENTATION WOULD BE AND THE ANTICIPATED CHALLENGES, AND EVALUATES THE WORK OF OTHER STAKEHOLDERS IN THE SPACE. ULTIMATELY, THE GOAL IS TO CREATE A DETAILED BLUEPRINT, A ROADMAP THAT LAYS OUT THE PATH FOR BRINGING ABOUT THE DESIRED SOLUTION, FOR SUPPRESSING THE TRANSMISSION OF PATHOGENS IN THE BUILT ENVIRONMENT.