Metis Foundation

THE METIS FOUNDATION IS AN ORGANIZATION DEDICATED TO ADVANCING CLINICALLY RELEVANT MEDICAL RESEARCH, ESPECIALLY WITHIN THE DEPARTMENT OF DEFENSE. WE SEEK TO FOSTER COLLABORATION AMONG GOVERNMENT, ACADEMIC AND INDUSTRY ENTITIES BY PROVIDING SCIENTIFIC, EDUCATIONAL, FINANCIAL AND PROJECT MANAGEMENT SUPPORT DURING THE CONDUCT OF FEDERALLY AND PRIVATELY SPONSORED RESEARCH, CLINICAL TRIALS AND EDUCATION.

HU00012120008 THE MILITARY CARDIOVASCULAR OUTCOMES RESEARCH (MICOR) PROGRAM UTILIZES A MULTIDISCIPLINARY APPROACH FOR DEFINING THE BEST PRACTICES TO PREVENT AND MITIGATE CARDIOVASCULAR DISEASE (CVD) IN THE MILITARY. THE MAJOR FOCUS IS TO INCREASE READINESS, REDUCE HEALTH COST, AND PREVENT CARDIOVASCULAR MORBIDITY LATER IN LIFE FOR VARIOUS MILITARY COHORTS. THE PROGRAM INTEGRATES A VARIETY OF SUBJECT MATTER EXPERTISE INCLUDING CARDIOLOGY, PHARMACOLOGY, PSYCHOLOGY, AND METABOLIC DISORDERS WHILE IMPLEMENTING CARDIOVASCULAR PREVENTION STRATEGIES IN A VARIETY OF POPULATIONS.

W81XWH-19-2-0038: APPLIED TISSUE TECHNOLOGIES IS WORKING ON THE REGENERATION OF EPIDERMIS AND DERMIS USING PIXELGRAFTING. THE UNIVERSITY OF PITTSBURGH IS WORKING ON THE RESTORATION OF THE HYPODERMIS. NORTHWESTERN UNIVERSITY IS EVALUATING THE EFFICACY OF BLOCKING THE SODIUM SIGNALING PATHWAY BY TOPICAL DRUG TREATMENT IN REDUCING SCARRING IN THE RABBIT EAR FULL THICKNESS BURN MODEL. THE USAISR IS WORKING ON THE PREVENTION OF SCARRING BY PRECISE DELIVERY OF STEROIDAL AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS.

W81XWH-20-2-0038 THI S PROGRAM AIMSTO DEVELOP A SKIN-LIKE EPIDERMAL SYSTEM WITH INTEGRATED RADIATION AND BIOSENSORS THAT IS WIRELESS ANDIMPERCEPTIBLE ON THE SKIN, HEREIN REFERRED TO AS THE EPIDERMAL-PATCH FOR IMPERCEPTIBLE CARE (EPIC) SYSTEM. THEEPIC SYSTEM IS A PROPRIETARY SYSTEM (PATENTS PENDING) DEVELOPED BY PROF. JOHN ROGERS AT NORTHWESTERNUNIVERSITY AND DR. ROOZBEH GHAFFARI AT EPICORE BIOSYSTEMS, INC. THE EPIC DEVICE IS COMPARABLE IN SIZE (~5 G) AND GEOMETRY (~2-MM THICK) TO A SOFT GAUZE BANDAGE (FIGURE). IT IS DISPOSABLE AND CONTAINS SOFT POLYMERIC SHEETSTHAT HOUSE HIGHLY FLEXIBLE ELECTRONICS COUPLED TO A THIN FILM PRIMARY CELL BATTERY, LOW-POWER ACCELEROMETERS,ULTRATHIN ELECTRODES, AND A NETWORK OF OPTICAL SENSORS CAPABLE OF MULTIPARAMETRIC SENSING OF BROAD ENVIRONMENTALAND PATHOPHYSIOLOGIC PARAMETERS SUCH AS ELECTROCARDIOGRAPHY (ECG), SWEAT RATE/COMPOSITION SENSING (LACTATE,PYRUVATE, CHLORIDE, GLUCOSE), PHOTOPLETHYSMOGRAPHY, SURFACE AND CORE BODY TEMPERATURE (SECONDARY TO DIRECTEDENERGY [DE] EXPOSURE SUCH AS MICROWAVE RADIATION)

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