Coalition For National Trauma Research

TO ENHANCE TRAUMA RESEARCH IN THE U.S. BY ADVOCATING FOR SUSTAINABLE RESEARCH FUNDING COMMENSURATE WITH THE BURDEN OF DISEASE; COORDINATE RESEARCH EFFORTS ACROSS PROFESSIONAL ORGANIZATIONS THAT SPAN THE CONTINUUM OF INJURY CARE; AND STRENGTHEN THE INFRASTRUCTURE FOR MULTICENTER INVESTIGATION.

NATIONAL TRAUMA RESEARCH REPOSITORY (NTRR) - THE PURPOSES OF THIS PROJECT ARE TO PREPARE TO FULLY INTEGRATE LEGACY DATA FROM THE NATIONAL TRAUMA RESEARCH REPOSITORY (NTRR) INTO THE FITBIR IS, CLEAN AND HARMONIZE STUDIES AGAINST ESTABLISHED AND NEW TRAUMA COMMON DATA ELEMENTS (CDES), INTEGRATE LEGACY DATA OF HIGH QUALITY THAT WILL SUPPORT SECONDARY ANALYSIS, AND ESTABLISH A SYSTEMS PROCESS FOR NEW SUBMISSION AND USE OF LEGACY DATA. IN 2023, CNTR ESTABLISHED STEERING COMMITTEES AND WORKGROUPS AND FACILITATED REGULAR MEETINGS TO MANAGE THE WORK, CONDUCTED AN ANALYSIS OF NTRR VERSION 1 CORE CDES AND FITBIR CDES, BEGAN TO IDENTIFY DATA ELEMENTS IF FOUR ENVIRONMENTS OF CARE FOR CONSIDERATION, AND DEVELOPED AN EVALUATION TOOL TO ASSESS THE RELEVANCE AND QUALITY OF LEGACY DATA.

PCORI VTE- THE PRIMARY OBJECTIVE OF THE PROJECT IS TO HELP NURSES AND PATIENTS MAKE INFORMED DECISIONS REGARDING VTE PREVENTION AND REDUCE THE OCCURRENCE OF BLOOD CLOTS IN INJURED PATIENTS BY 1) IMPLEMENTING A VALIDATED NURSE EDUCATION MODULE, AND PATIENT-CENTERED EDUCATION TOOL AT 9 TRAUMA CENTERS, 2) EXAMINING DATA ON MISSED AND REFUSED DOSES OF VTE PROPHYLAXIS AND STUDY THE INTERVENTION'S IMPACT ON VTE OUTCOMES IN TRAUMA PATIENTS AT HIGH-RISK FOR VTE EVENTS, AND 3) CONDUCTING A QUALITATIVE STUDY TO TAILOR THE INTERVENTION TO THE DIFFERENT HEALTH CARE SETTINGS AND COMPUTER SYSTEMS SO THAT IT CAN BE IMPLEMENTED NATIONALLY. MORE THAN 1,000 NURSES HAVE COMPLETED THE NURSE EDUCATION TRAINING, AND NURSE PEER COACHING WAS PROVIDED TO ALL 9 TRAUMA CENTERS, A REAL-TIME MISSED DOSE ALERT WAS PUT INTO PLACE AT ALL SITES, AND THE PATIENT EDUCATION PROGRAM WAS ACTIVATED. ALL 9 SITES ARE ACTIVELY SUBMITTING TRAUMA REGISTRY AND MISSED DOSE DATA FOR TRAUMA ADMISSIONS FROM JANUARY 1, 2019-DECEMBER 31, 2023. A CNTR WEBPAGE WAS CONTINUOUSLY UTILIZED AS A REPOSITORY FOR ALL STUDY EDUCATIONAL MATERIALS. A DELPHI SURVEY ON PERI-PROCEDURAL VTE PROPHYLAXIS WAS COMPLETED AND A PUBLICATION IS IN PROGRESS.

PROPOLIS - THE PROPOLIS (PLASMA RESUSCITATION WITHOUT LUNG INJURY) STUDY EXAMINES THE USE OF INTERCEPT-TREATED PATHOGEN-REDUCED PLASMA (IPRP) IN THE RESUSCITATION OF BURNED PATIENTS. IPRP IS AN FDA-APPROVED BLOOD COMPONENT THAT HAS UNDERGONE TREATMENT TO REDUCE THE RISK OF TRANSFUSION-TRANSMITTED INFECTION. THIS IS A THREE-YEAR STUDY, FUNDED BY THE DEFENSE MEDICAL RESEARCH AND DEVELOPMENT PROGRAM. AS THE COORDINATING CENTER FOR THE MULTI-INSTITUTIONAL STUDY, CNTR IS RESPONSIBLE FOR END-TO-END STUDY MANAGEMENT ACROSS FIVE CLINICAL SITES AND TWO LABORATORIES INVOLVING ALL POLICY AND PROCEDURE, TRAINING, AND HUMAN SUBJECT PROTECTION ACTIVITIES. DUE TO LOW ENROLLMENT, CNTR FACILITATED A PROTOCOL AMENDEMENT TO EXTEND THE ENROLLMENT WINDOW TO 18 HOURS.